Chapel Hill Low Back Pain Blog Has Lots of Information
I have really enjoyed reading the Chapel Hill low back pain blog.? My husband was the first to read the blog and he was actually reading about caffeine.? However, he told me that there were so many different articles that he thought I might enjoy.? Since I run a?lot, I have been reading about barefoot running and plantar fascitis.? Someone had asked him to talk about stretches for the foot which I am also very interested in.? I assume that he probably will as he updates his blog at least weekly.? Also, he has some traveling pictures on his blog that are really cool.
Help Seniors Stay Safe At Home With Home Care Services in ...
Home Care Services in Bellevue WA Helps Seniors Stay Safe At Home SERVICES TO HELP YOU STAY AT HOME
Many older adults prefer to stay at home as they age. But is this the right choice for you? The goal of home care is to help you remain at home as long as possible, rather than moving into a long?term care facility. It may be right for you if you only need minor assistance with your daily activities and enjoy a close network of nearby family and friends. ?There is a wide range of?home care services that can help you maintain your independence within the comfort of your own home. Learn about your options, explore how to choose the right home care service provider, and find tips for discussing concerns with your loved ones.
Is home care right for my loved one or me? It?s natural to want to stay at home as you grow older?most seniors hope to be able to. However, taking a step back to look at the big picture can help you decide whether staying at home for the long term truly is the right step for you. Too often, decisions to leave home are suddenly made after a sudden loss or emergency, making adjustments all the more painful and difficult. Take a look at your options, your budget, and some of the alternatives.
Deciding whether to stay at home Your home situation is unique, and several factors will weigh in on the best choice for you. Here are some of the issues in evaluating your options:
Location and accessibility. Where is your home located? Are you in a rural or suburban area that requires a lot of driving? If you?re in an area with more public transit, is it safe and easily accessible? How much time does it take you to get to services such as shopping or medical appointments?
Home accessibility and maintenance. Is your home easily modified? Does it have a lot of steps, stairs or a steep hill to access? Do you have a large yard that needs to be maintained?
Support available. Do you have family and friends nearby? How involved are they? Are they able to provide you the support you need? Many older adults prefer to rely on family to provide help, but as your needs increase, they might not be able to fill in all of the gaps. It?s important to consider proximity to community services and activities as well.
Isolation. If it becomes difficult or impossible for you to leave home without help, isolation can rapidly set in. You may not be able to participate in hobbies you once loved, stay involved in community service that kept you motivated, or visit with friends and family. Losing these connections and support is a recipe for depression.
continue reading from helpguide.org
If you are interested in learning more about?home care services in the Bellevue area, contact the caregivers at?Andelcare. We specialize in helping our seniors, veterans and disabled with quality and affordable home care options. Call?425-283-0408.
Wisconsin Governor Walker to face recall vote on June 5
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Whitney Houston daughter lands role in Tyler Perry show
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From food to silverware, ten retail businesses explode readily ...
This may sound like semantic nit picking but it is important to understand.
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You can still avail lines of credit. The funding source analyzes your moving business past credit card sales. In such a situation, we need the cash from external sources, and what better way than to take it as a line of credit from a cheap as well as a reliable source. A slightly higher rate of interest might be required to pay.
You can easily avail a loan. However, a good research can help you get better interest rate deals and also restaurant finance. There are many private financing companies which offer a window washing business cash advance or similar program. Just keep in mind that you need to check the expiration date on all supplies you purchase prior to using. After purchasing products, materials, and a location a person will find that they have accumulated a lot of debt.
If you decide to take this route, make sure to order from a reputable online source. Name brands need to be purchased straight from the company or you can purchase them at a salon. Restaurants have received an unjust standing for being extremely prone to going under, making it incredibly complicated for flourishing restaurateurs to acquire unsecured bus company loans. If youre looking to start a bus company then I would look no further than the internet. They can start a sporting goods store from scratch or they can buy into another company as an affiliate or franchise owner. Users of both Social Networking Sites love their favorite eating places and will follow these on social networking sites like Twitter and Facebook where they expect to find fair deals that are available on company sponsored pages. Funders now require several months of past credit card statements and restrict the types of industries they approve for funding.
merchant cash advance reviews for sporting goods stores selling electronics
The price is usually higher, but you are paying for high quality. You have to be relieved with your purchase and so do your customers. Check out the return policy that the company offers.
At last, for a new financier, a lower amount of poignant essentials for approval will effectively foster the potential of acquiring the much desired assets. When you possess a restaurant you generally catch yourself in dire need of urgent funding for renovations or additional costs.
29 March 2012Last updated at 06:47 ETBy Jonathan AmosScience correspondent, BBC News, Manchester
Scientists have produced a colossal picture of our Milky Way Galaxy, to reveal the detail of a billion stars.
It is built from thousands of individual images acquired by two UK-developed telescopes operating in Hawaii and in Chile.
Archived data from the project, known as the Vista Data Flow System, will be mined by astronomers to make new discoveries about the local cosmos.
But more simply, it represents a fabulous portrait of the night sky.
"There are about one billion stars in there - this is more than has been in any other image produced by surveys," said Dr Nick Cross from the University of Edinburgh.
"When it was first produced, I played with it for hours; it's just stunning," he told BBC News.
Dr Cross has been presenting the new work to the UK National Astronomy Meeting (NAM) here in Manchester.
The image concentrates on the dense plane of the galaxy, which means it renders as a very long, very thin strip.
That makes it is virtually impossible to show in a meaningful way on this page.
Dr Cross and colleagues have though produced an online interactive tool that allows the user to zoom in to particular areas. Even then, these smaller fragments of sky will contain thousands of stars.
The project has been 10 years in the making. It combines data from the UKIDSS/GPS sky survey acquired by the UK Infrared Telescope in Hawaii with the VVV survey data acquired by the Vista telescope in Chile.
These astronomical facilities view the sky at infrared wavelengths, enabling them to see past the dust in the Milky Way that would ordinarily obscure observations made at optical, or visible, wavelengths.
UKIRT is responsible for the right end of the image; Vista produced the left, including the more extensive block of coverage which traces the centre of the galaxy and its surrounding bulge of stars. (Black squares in the image are data gaps that are in the process of being filled).
Researchers at the universities of Edinburgh and Cambridge processed and archived all the data that underpins the big picture, and have made it available to astronomers around the world for future study.
"There are many uses for this picture," said Dr Cross. "It will help us really understand the true nature of our galaxy, to see where everything is.
"Some researchers will use it to find star forming regions; there'll be lots of these along the plane of the galaxy.
"Finding globular clusters will be another use. These are groups of very old stars that formed right at the beginning of the galaxy. We can study their distribution in this image and that tells us something about how the Milky Way started off.
"And it will be particularly useful to study anything that is extended. Here you can look at things on the large scale, to understand how they are related to each other; to look at things that might be across multiple images in a catalogue.
"These are the big objects like clusters, and nebulae - the gas clouds where stars are forming."
Jonathan.Amos-INTERNET@bbc.co.uk and follow me on Twitter
Include the Doctor Value: Pleasing Traits of a Cosmetic Surgeon
Women who opt to go through any cosmetic surgery have differing preferences when it comes to the time for having it done.. Some women opt to go under the knife when they believe that it is the right time, while others wait until the signs of aging kick in. Regardless of timing, all women wishing to undergo cosmetic surgery really should first find a reputable cosmetic surgeon.
Cosmetic surgeons put a patient's life and physical transformation in their hands quite literally. A surgeon's skill and expertise are the secret ingredients in aiding a patient to change the way s/he appears. That is why choosing the best cosmetic surgeon can take time and energy; nonetheless, this can make the surgical treatment beneficial.
A good cosmetic surgeon is someone you can talk to about the treatment.
This means that both the patient and the surgeon should communicate about the plans and objectives of the surgery. Surgeons can prescribe the best type of aesthetic therapy to patients, but they should also listen to their clients' issues.
Adept cosmetic surgeons are also board certified and licensed to work in their field of specialization. Cosmetic Surgeons spend many years of hard work to attain the required abilities, expertise, and experience to successfully and safely provide their services. Additionally, these surgeons use their talents to focus on a particular reconstructive therapy.
Besides being competent, cosmetic surgeons are also resilient. They can quickly adjust when a patient needs to set another appointment for a surgical treatment, or if the patient changes his/her mind.
Furthermore, good cosmetic surgeons in San Francisco can keep up with the current advancements in the field and they include new techniques or technologies into the services they offer.
It can also be said that cosmetic surgeons must have a keen eye for aesthetics. Cosmetic surgery is not just science but a work of art, which is why doctors really should have the potential to know what is best for their clients. This implies that they ought to have an understanding of their patient's body in terms of proportion and appeal. A website of a cosmetic surgeon San Francisco ladies prefer has pictures of before-and-after breast augmentation surgeries that help prospective clients see if these are the results they want to get.
Finally, trustworthy surgeons know that there should be integrity in everything they do. That is why the cosmetic surgeons San Francisco has offer a safe and reliable surgical process. These cosmetic surgeons' teams are also trained to monitor and accommodate patients throughout the therapy.
Gordon Ramsay settles with ex-editor over hacked emails
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Related posts:
Starting Tiny Company ? Organizing And Mindset Are The Basic Principles
Tips On Starting A Corporate Training Company
Steps To Starting Your Commercial Cleaning Company
Planning Is The Most Important Part Of Starting A Home Business.
Adjuvanted flu vaccine associated with child narcolepsy in Finland
Adjuvanted flu vaccine associated with child narcolepsy in FinlandPublic release date: 28-Mar-2012 [ | E-mail | Share ]
Contact: Yael Franco yfranco@plos.org 415-568-3169 Public Library of Science
A sudden increase in narcolepsy in Finnish children at the beginning of 2010 was likely related to the Pandemrix vaccine used in response to the H1N1 2009 flu pandemic, according to two reports published Mar. 28 in the open access journal PLoS ONE.
The authors of the studies, led by Markku Partinen of the Helsinki Sleep Clinic and Hanna Nohynek of the National Institute for Health and Welfare in Finland, found that the average annual incidence of narcolepsy between 2002 and 2009 among children younger than 17 was 0.31 per 100,000, and in 2010, this incidence was about 17 times higher, at 5.3 cases per 100,000. In contrast, the incidence rate for adults over 20 was essentially unchanged over that same time period.
To further evaluate the potential connection between the vaccine and narcolepsy, the researchers collected vaccination and childhood narcolepsy data for children born between January 1991 and December 2005.
They found that the narcolepsy incidence for vaccinated individuals within this age group was 9.0 per 100,000 people, as compared to just 0.7 per 100,000 for unvaccinated individuals almost 13 times lower.
Together, these results provide compelling evidence that the Pandemrix vaccine, used in 2009 and 2010 in association with the H1N1 flu pandemic, contributed to narcolepsy in patients between the age of 4 and 19 in Finland, the authors conclude.
###
Citation: Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, et al. (2012) AS03 Adjuvanted AH1N1 Vaccine Associated with an Abrupt Increase in the Incidence of Childhood Narcolepsy in Finland. PLoS ONE 7(3): e33536. doi:10.1371/journal.pone.0033536
Citation: Partinen M, Saarenpaa-Heikkila O, Ilveskoski I, Hublin C, Linna M, et al. (2012) Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland. PLoS ONE 7(3): e33723. doi:10.1371/journal.pone.0033723
Financial Disclosure: The following organizations funded the study: National Institute for Health and Welfare (THL) and Ministry of Social Affairs and Health, Finland. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Financial Disclosure: The authors have no external support or funding to report. The collection of data from the registries and from different hospitals was funded by THL. The study group had freedom for the study design, data collection, data analysis, data interpretation, and writing of the report. The authors had access to all the data, take responsibility for the integrity of the data and the accuracy of the analysis, and had final responsibility for the reporting of the data.
Competing Interest Statement: HN received honoraria for technical consultancy from GlaxoSmithKline (GSK), and Pfizer for development of pneumococcal conjugate vaccines. JJ is co-investigator of a nationwide effectiveness study of the ten-valent pneumococcal conjugate vaccine mainly funded by GlaxoSmithKline. MP has been consultant for Bioprojet and UCB Pharma and received funding support and travel grants from Boehringer-Ingelheim, Bioprojet, GSK, Cephalin, MSD, Leiras and Servier. T. Kilpi is principal investigator of a nationwide effectiveness study of the ten-valent pneumococcal conjugate vaccine mainly funded by GlaxoSmithKline, and her unit received funding for a clinical trial on the safety and immunogenicity of a prototype pandemic influenza vaccine from Solvay Pharmaceuticals. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. All other authors confirm they have no conflicts of interest.
Competing Interest Statement: The authors have declared that no competing interests exist.
Disclaimer: This press release refers to upcoming articles in PLoS ONE. The releases have been provided by the article authors and/or journal staff. Any opinions expressed in these are the personal views of the contributors, and do not necessarily represent the views or policies of PLoS. PLoS expressly disclaims any and all warranties and liability in connection with the information found in the release and article and your use of such information.
About PLoS ONE
PLoS ONE is the first journal of primary research from all areas of science to employ a combination of peer review and post-publication rating and commenting, to maximize the impact of every report it publishes. PLoS ONE is published by the Public Library of Science (PLoS), the open-access publisher whose goal is to make the world's scientific and medical literature a public resource.
All works published in PLoS ONE are Open Access. Everything is immediately availableto read, download, redistribute, include in databases and otherwise usewithout cost to anyone, anywhere, subject only to the condition that the original authors and source are properly attributed. For more information about PLoS ONE relevant to journalists, bloggers and press officers, including details of our press release process and our embargo policy, see the everyONE blog at http://everyone.plos.org/media.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Adjuvanted flu vaccine associated with child narcolepsy in FinlandPublic release date: 28-Mar-2012 [ | E-mail | Share ]
Contact: Yael Franco yfranco@plos.org 415-568-3169 Public Library of Science
A sudden increase in narcolepsy in Finnish children at the beginning of 2010 was likely related to the Pandemrix vaccine used in response to the H1N1 2009 flu pandemic, according to two reports published Mar. 28 in the open access journal PLoS ONE.
The authors of the studies, led by Markku Partinen of the Helsinki Sleep Clinic and Hanna Nohynek of the National Institute for Health and Welfare in Finland, found that the average annual incidence of narcolepsy between 2002 and 2009 among children younger than 17 was 0.31 per 100,000, and in 2010, this incidence was about 17 times higher, at 5.3 cases per 100,000. In contrast, the incidence rate for adults over 20 was essentially unchanged over that same time period.
To further evaluate the potential connection between the vaccine and narcolepsy, the researchers collected vaccination and childhood narcolepsy data for children born between January 1991 and December 2005.
They found that the narcolepsy incidence for vaccinated individuals within this age group was 9.0 per 100,000 people, as compared to just 0.7 per 100,000 for unvaccinated individuals almost 13 times lower.
Together, these results provide compelling evidence that the Pandemrix vaccine, used in 2009 and 2010 in association with the H1N1 flu pandemic, contributed to narcolepsy in patients between the age of 4 and 19 in Finland, the authors conclude.
###
Citation: Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, et al. (2012) AS03 Adjuvanted AH1N1 Vaccine Associated with an Abrupt Increase in the Incidence of Childhood Narcolepsy in Finland. PLoS ONE 7(3): e33536. doi:10.1371/journal.pone.0033536
Citation: Partinen M, Saarenpaa-Heikkila O, Ilveskoski I, Hublin C, Linna M, et al. (2012) Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland. PLoS ONE 7(3): e33723. doi:10.1371/journal.pone.0033723
Financial Disclosure: The following organizations funded the study: National Institute for Health and Welfare (THL) and Ministry of Social Affairs and Health, Finland. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Financial Disclosure: The authors have no external support or funding to report. The collection of data from the registries and from different hospitals was funded by THL. The study group had freedom for the study design, data collection, data analysis, data interpretation, and writing of the report. The authors had access to all the data, take responsibility for the integrity of the data and the accuracy of the analysis, and had final responsibility for the reporting of the data.
Competing Interest Statement: HN received honoraria for technical consultancy from GlaxoSmithKline (GSK), and Pfizer for development of pneumococcal conjugate vaccines. JJ is co-investigator of a nationwide effectiveness study of the ten-valent pneumococcal conjugate vaccine mainly funded by GlaxoSmithKline. MP has been consultant for Bioprojet and UCB Pharma and received funding support and travel grants from Boehringer-Ingelheim, Bioprojet, GSK, Cephalin, MSD, Leiras and Servier. T. Kilpi is principal investigator of a nationwide effectiveness study of the ten-valent pneumococcal conjugate vaccine mainly funded by GlaxoSmithKline, and her unit received funding for a clinical trial on the safety and immunogenicity of a prototype pandemic influenza vaccine from Solvay Pharmaceuticals. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. All other authors confirm they have no conflicts of interest.
Competing Interest Statement: The authors have declared that no competing interests exist.
Disclaimer: This press release refers to upcoming articles in PLoS ONE. The releases have been provided by the article authors and/or journal staff. Any opinions expressed in these are the personal views of the contributors, and do not necessarily represent the views or policies of PLoS. PLoS expressly disclaims any and all warranties and liability in connection with the information found in the release and article and your use of such information.
About PLoS ONE
PLoS ONE is the first journal of primary research from all areas of science to employ a combination of peer review and post-publication rating and commenting, to maximize the impact of every report it publishes. PLoS ONE is published by the Public Library of Science (PLoS), the open-access publisher whose goal is to make the world's scientific and medical literature a public resource.
All works published in PLoS ONE are Open Access. Everything is immediately availableto read, download, redistribute, include in databases and otherwise usewithout cost to anyone, anywhere, subject only to the condition that the original authors and source are properly attributed. For more information about PLoS ONE relevant to journalists, bloggers and press officers, including details of our press release process and our embargo policy, see the everyONE blog at http://everyone.plos.org/media.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
NEW YORK (AP) ? Will Ferrell's swashbuckling newscaster Ron Burgundy had his own breaking news to announce Wednesday night: A sequel to "Anchorman" is finally happening.
Ferrell made a surprise, in-character appearance on "Conan" to regale the audience with a flute solo and declare a deal with Paramount Pictures. A sequel to the 2004 hit comedy, "Anchorman: The Legend of Ron Burgundy," has long been discussed.
Ferrell informed host Conan O'Brien: "It's official, there will be a sequel to 'Anchorman.'"
Earlier, Paramount had declined a musical plan put forth by Ferrell and director Adam McKay that also included a proposed Broadway stage show. No details on the project were immediately available but McKay, producer Judd Apatow, and co-stars Paul Rudd and Steve Carell are expected to return.
SEOUL, South Korea (AP) ? President Barack Obama said Tuesday he is not trying to "hide the ball" in negotiations with Russia over U.S. plans for a missile defense shield in Europe, trying to put to rest a controversy over comments to Russia's leader that were picked up by an open microphone and quickly drew fire from Republican presidential contenders in America.
Republicans had pounced on Obama's remarks to Russian President Dmitry Medvedev on Monday that he would have more room to negotiate on the issue after the November presidential election, accusing the president of having a hidden agenda that could include concessions to the Russians if he is re-elected this fall.
Obama's conversation was picked up by a microphone without either leader apparently knowing.
"This is my last election," Obama was heard telling Medvedev, Russia's outgoing president. "After my election, I have more flexibility."
A day later, with election-year political machinery in full gear, Obama sought to clarify.
"I want to reduce our nuclear stockpiles. And one of the barriers to doing that is building trust and cooperation around missile defense issues," he said while he and Medvedev made a separate announcement about nuclear materials cleanup on the sidelines of a major security conference here.
"And so this is not a matter of hiding the ball," Obama said. "I'm on record."
Obama was prepared and eager to clarify his caught-on-tape words even at the risk of overshadowing his message for a second day about nuclear security efforts. In talking to reporters, however, he never answered a question about the presumptuousness of plotting out 2013 strategy with Russia when, in fact, he must win election again for any of that to matter.
For Russia, the issues of nuclear weapons reduction and the proposed missile shield are related. Russian fears of new U.S. missiles at its doorstep in Europe have helped to stymie further progress on nuclear arms reductions after a breakthrough agreement two years ago.
Obama said he wants to spend the rest of this year working through technical issues with the Russians, and said it was not surprising that a deal couldn't be completed quickly.
"I don't think it's any surprise that you can't start that a few months before presidential and congressional elections in the United States, and at a time when they just completed elections in Russia, and they're in the process of a presidential transition," Obama told reporters Tuesday.
He also made light of the controversy, jokingly asking whether the microphones were switched on before he spoke.
"The only way I get this stuff done is if I'm consulting with the Pentagon, if I'm consulting with Congress, if I've got bipartisan support, and the current environment is not conducive to those kinds of thoughtful consultations," Obama said.
"I think we'll do better in 2013."
Neither Obama nor Medvedev knew they were being heard when they conferred quietly at what was billed as their last meeting of Medvedev's presidency. He leaves office in May, to be replaced by the incoming Vladimir Putin.
According to ABC News, Medvedev replied in English: "I understand. I will transmit this information to Vladimir," an apparent reference to incoming President Vladmir Putin.
The White House said Obama's words reflected the reality that domestic political concerns in both the U.S. and Russia this year would make it difficult to fully address their long-standing differences over the contentious issue of missile defense. Obama, should he win re-election, would not have to face voters again.
Obama's candid remarks Monday illustrated the political constraints that hem in any president who is running for re-election and dealing with a congressional chamber ? in this case, the House ? controlled by the rival party.
Republicans have fought Obama fiercely on health care, taxes and other issues. They are eager to deny him any political victories in a season in which they feel the White House is within reach, although Obama's remarks suggested he feels good about his re-election prospects.
Mitt Romney, the leading Republican contender to face Obama this fall, told a San Diego audience the unguarded comments were "an alarming and troubling development."
"This is no time for our president to be pulling his punches with the American people, and not telling us what he's intending to do with regards to our missile defense system, with regards to our military might and with regards to our commitment to Israel," Romney said.
Romney, a former Massachusetts governor who often faces charges of having been flexible on his own policies over the years, also issued a statement saying Obama "needs to level with the American public about his real agenda."
Obama campaign spokesman Ben LaBolt said Romney "is undermining his credibility by distorting the president's words."
Republican presidential candidate Newt Gingrich also questioned Obama's motives.
"I'm curious, how many other countries has the president promised that he'd have a lot more flexibility the morning he doesn't have to answer to the American people?" Gingrich said on CNN.
Rep. Mike Turner of Ohio, Republican chairman of the House Armed Services Subcommittee on Strategic Forces, wrote to the president requesting an "urgent explanation of (his) comments." Turner said Congress "has made exquisitely clear to your administration and to other nations that it will block all attempts to weaken U.S. missile defenses."
The Republicans' sharp remarks underscore increased willingness of politicians to criticize a president on a foreign trip. The old adage "politics ends at the water's edge" is a casualty of the nation's heightened partisanship in recent decades.
Obama said the way the Republicans seized on his open-mic comments only made his point that the atmosphere is too politicized right now to advance arms control with Russia.
Congress, as part of the fiscal 2012 defense authorization act, constrained Obama's ability to share classified U.S. missile defense information with Russia. Obama signed that legislation into law.
Putin said earlier this month that Washington's refusal to offer Moscow written guarantees that its missile defense system would not be aimed against Russia deepened its concerns.
___
AP White House Correspondent Ben Feller in Seoul, South Korea, Associated Press writers Kasie Hunt in San Diego and Donna Cassata in Washington contributed to this report. Babington reported from Washington.
SEOUL, South Korea (AP) ? Material that can be used to make nuclear bombs is stored in scores of buildings spread across dozens of countries. If even a fraction of it fell into the hands of terrorists, it could be disastrous.
Nearly 60 world leaders who gathered Tuesday in Seoul for a nuclear security summit agreed to work on securing and accounting for all nuclear material by 2014. But widespread fear lingers about the safety of nuclear material in countries including former Soviet states, Pakistan, North Korea, Iran and India.
While the threat of nuclear terrorism is considered lower now than a decade ago, especially after the death of Osama bin Laden, the nightmare scenario of a terrorist exploding a nuclear bomb in a major city isn't necessarily the far-fetched stuff of movies.
"It would not take much, just a handful or so of these materials, to kill hundreds of thousands of innocent people and that's not an exaggeration, that's the reality that we face," President Barack Obama told world leaders at the meeting, a follow-up to a summit he hosted in Washington in 2010.
Building a nuclear weapon isn't easy, but a bomb similar to the one that obliterated Hiroshima is "very plausibly within the capabilities of a sophisticated terrorist group," according to Matthew Bunn, an associate professor at Harvard University's John F. Kennedy School of Government.
There's an "immense difference between the difficulty of making safe, reliable weapons for use in a missile or combat aircraft and making crude, unsafe, unreliable weapons for delivery by truck," Bunn said.
The Nuclear Threat Initiative, a Washington-based nonproliferation group that tracks the security of world nuclear stockpiles, said in a January report that 32 countries have weapons-usable nuclear materials. Some countries, such as the United States, maintain strict controls already. However others, including Russia and other former Soviet republics, have struggled to secure their stocks, raising fears of "loose nukes" falling into the hands of terrorist groups.
It's unclear how nations will enforce the summit's goal of securing nuclear material by 2014. The International Atomic Energy Agency shares best practices for securing nuclear material, but the U.N. body has no power to enforce its recommendations.
Some countries on the NTI list are a concern because of their government's ties with militant groups or because of corruption among their officials. Others simply don't yet have good safety practices.
Although Pakistan's small stockpiles of nuclear material are heavily guarded, it is believed to be prone to corruption by officials who may have sympathies to hard-line Islamic militants, Bunn said.
Despite New Delhi's insistence that its nuclear materials are secure, the NTI ranked India among the top five nuclear security risks, saying the government needs more transparency, more independence for its nuclear regulator and tighter measures to protect nuclear material in transit.
India's lax security was displayed in at least two incidents in recent years in which radioactive materials ? from a hospital and a university laboratory ? were discarded and later ended up in a scrap dealer's shop.
Other recent nuclear scares include a suspected attempt by a crime syndicate in the eastern European country of Moldova to sell weapons-grade uranium to buyers in North Africa. Officials in the country told The Associated Press that 1 kilogram (2.2 pounds) of highly enriched uranium remains in criminal hands and is probably in another country.
The investigation provided fresh evidence of a black market in nuclear material probably taken from poorly secured Soviet stockpiles.
Russia has dramatically improved its nuclear security over the last 15 years, Bunn said, but it has the "world's largest stockpiles in the world's largest number of buildings and bunkers" as well as corruption and a weak security culture and regulations.
North Korea and Iran are viewed with worry because of fears of nuclear proliferation.
But Bunn said both are "likely small parts of the nuclear terrorism problem."
"North Korea has only a few bombs' worth of plutonium in a tightly controlled garrison state," he said. "Iran has not begun to produce weapons-usable material."
At least four terror groups, including al-Qaida and Japan's Aum Shinrikyo doomsday cult, have expressed a determination to obtain a nuclear weapon, said Kenneth Luongo, co-chair of the Fissile Materials Working Group, a Washington-based coalition of nuclear security experts.
Nuclear materials stored at research facilities are generally considered less secure than weapons at military installations, Luongo said. Last year's meltdown at Japan's Fukushima nuclear power plant also shows how terrorists could launch a radiation hazard simply by sabotaging a facility's functions.
While some groups could develop crude missiles or other delivery systems, unconventional weapons such as a single briefcase containing plutonium and a detonator may be an even bigger threat, said Chang Soon-heung, a nuclear expert at the Korea Advanced Institute of Science and technology.
Nuclear security experts say greater political commitment is needed to drive efforts to secure radioactive materials and overcome barriers to international cooperation.
While experts praised this week's nuclear summit as a sign of progress, some doubted whether countries would meet the 2014 deadline for securing the world's loose nuclear material, defined generally as completed weapons, bomb material, or the skills to build them.
"There needs to be more political leadership from the top, and countries need to stop talking about what they're doing individually and acknowledge that this is a cross-border international issue," Luongo said.
___
AP writers Sam Kim in Seoul and Nirmala George in New Delhi contributed to this report.
Doc's Talk: Weapon against pancreatic and prostate cancer
Abigail Klein Leichman March 19, 2012
An Israeli pharma company is testing an advanced compound that blocks a tumor's blood supply. Used with standard chemo, it obliterates the growth. Tiltan COO Dan Goldstaub, PhD.
Last year, about 44,000 Americans were diagnosed with pancreatic cancer, a notoriously resistant cancer to treat and the fourth most common cause of cancer-related death for men and women.
The prognosis for these patients could improve drastically if a compound developed by Israel's Tiltan Pharma continues to succeed in clinical trials.
The compound, dubbed TL-118, comes from the labs of the Hebrew University of Jerusalem. It's now undergoing its second phase of tests after proving effective against pancreatic tumors first in mice and then in more than 100 humans.
Chief operating officer Dan Goldstaub explains that the company's approach is based on a relatively new understanding of how cancerous tumors grow. Through an abnormal process called angiogenesis, the tumors "recruit" blood vessels from neighboring tissue. Anti-angiogenic therapy is a revolutionary approach aimed at disrupting this process by blocking the tumor's blood supply.
"Theoretically, we can treat all solid tumors this way," Goldstaub tells ISRAEL21c. "However, some tumors are more susceptible to angiogenesis inhibition, and each tumor uses different mechanisms of angiogenesis." Several other drug developers have developed anti-angiogenic agents that block a single biological pathway. Tiltan's approach is more aggressive. "Our product inhibits four different pathways, so even if we achieve mild inhibition on each pathway, the cumulative effect is broader," says Goldstaub.
This breakthrough came out of a decade of research by Hebrew University-Hadassah Medical School Prof. Muli Ben-Sasson, scientific founder of Tiltan Pharma. Ben-Sasson worked for years with Judah Folkman, the Harvard professor who discovered the process of tumor angiogenesis.
"Dr. Ben-Sasson realized years ago what we now know for certain: that angiogenesis is too complex a mechanism to disrupt with a single agent," says Goldstaub, "so he came up with the idea of taking a few agents and combining them together. He looked for components of the angiogenic process and searched for drugs already approved for other indications that might inhibit those mechanisms."
After many attempts, Ben-Sasson hit upon the winning formula for TL-118. Based on preliminary results in animals and humans, Tiltan Pharma decided to test it specifically on people with pancreatic and prostate cancer.
Works together with standard chemo
In pre-clinical trials, TL-118 inhibited tumor growth significantly, compared to the standard-of-care chemotherapy. When it was combined with chemotherapy, it really packed a punch, abolishing the tumors completely in all treated animals.
The Phase 2 study in three Israeli oncology centers will follow the same model. Forty patients with metastatic pancreatic cancer not yet treated by chemotherapy will get the standard chemo. Forty others will have TL-118 added to their regimen as once-daily oral solution.
"We don't want to deprive patients of their chemotherapy, yet we do need to have a control for comparison, to show that we are better than the standard of care," says Goldstaub.
Trials have already begun at Hadassah Medical Center and at the Tel Aviv Sourasky Medical Center. Other sites will be added as more participants are recruited. At the same time, about 50 prostate cancer patients are also involved in Phase 2 TL-118 trials in Israel.
The US Food and Drug Administration has given its approval for Tiltan to test TL-118 in the United States, and the compound may also be tested in Eastern Europe soon. This will happen "when we complete another round of investment," says Goldstaub, a molecular geneticist who previously headed clinical programs for Teva Pharmaceuticals' Innovative R&D Division.
The small biotechnology company is located on the Givat Ram campus of the Hebrew University and is jointly owned by Yissum, the university's technology transfer company; its entrepreneurs; and Israeli and Canadian investors. Tiltan's research and development team includes pharmacists, pharmacologists, CMC (chemistry, manufacturing, and control) specialists and a clinical research associate.
Tiltan Pharma will be one of the portfolio companies of Integra Holdings, now being formed by Yissum. As Goldstaub explains "The holding company allows for financing Yissum's daughter companies and [simultaneously] allows investors to invest in a whole basket of development companies."
Weight-loss, Diet program, Health, Health and fitness, And Eating ...
March 27, 2012rosiadresses31Business
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Public release date: 28-Mar-2012
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